Bull Rankings model

BeOne Medicines AG (ONC) stock analysis

Biotechnology. Scored on the same transparent model behind the daily rankings.

★
ONC
BeOne Medicines AG · Biotechnology
67.8Score
$354.47Oct 9 close$40.3B
1Y Target$435.53Analyst consensus · 27 analysts
5Y Target$637.67Compound horizon
10Y Target$945.93Long-dated conviction
FCF$1.3bTTM · 06/26
C+
FCF $1.3b — respectable but not differentiating · TTM from SEC filings (OCF − CapEx), four quarters to 06/26.
Rev+34.3%TTM YoY
A
Revenue +34.3% — hypergrowth, top decile · Latest four quarters of revenue vs the four before them, from SEC filings.
D/E0.40
B
D/E 0.40 — near the Healthcare debt median (≈60th pctile)
P/E63.4x
C
P/E 63.4 — expensive vs Healthcare peers (≈90th pctile)
PEG0.74
A-
PEG 0.74 — strong; the growth comes cheap

Targets: 1-year is analyst consensus where covered, 5- and 10-year are model estimates; the DCF is a cross-check, not a target. Methodology

Quality-growth score · 67.8
Quality60.4
Growth95.0
Value54.4
Why this score
  • Diluting shareholders
Entry · Margin of safety
52-week rangeNear 52-week high
8% off the 12-month high
vs DCF fair value10% belowest. fair value ~$395
What the price assumes: free cash flow growing about 12% next year, slowing to 4% a year by year ten — vs a starting rate of ~25% our model takes as the middle of three readings — analyst estimates, last year's revenue growth, and the company's own multi-year record.
Quality signals
Gross profitability63% · Agross profit ÷ total assets — not in the score
ROIC11.5% · Breturn on invested capital — leads the quality score

Model-generatedWritten from the fundamentals then; figures in the text are as of that day, today's are above · Editorial standards

Why now
BeOne’s blockbuster BTK inhibitor BRUKINSA is driving a 34.3% revenue growth run‑rate while the business sustains a 10.7% profit margin and trades at a PEG of 0.77, underscoring outsized earnings expansion at a reasonable multiple. Our Bull Rankings model gives ONC a 70.4 quality‑growth score, with Growth as the strongest pillar, confirming that the pipeline’s near‑term launches will keep compounding earnings for years to come. The thesis rests on BRUKINSA’s expanding indication set and its ability to keep the growth engine humming.
Moat
BRUKINSA’s small‑molecule BTK inhibition platform commands a differentiated mechanism that is hard to replicate, giving BeOne pricing power in the blood‑cancer market and delivering a ROE of 12.7% that reflects superior returns on invested capital. The company’s global commercial footprint across the U.S., China and Europe creates high switching costs for oncologists accustomed to its regimen, cementing a durable competitive edge.
Risk
The price already embeds a P/E of 65.1, far above sector averages, and the Bull Rankings model flags diluting shareholders, meaning any aggressive buy‑back or share‑issuance could erode per‑share earnings. If BRUKINSA’s next‑line trials stumble or reimbursement pressures tighten, the high multiple will compress sharply, confirming the bear case. A sustained rise in debt‑to‑equity beyond 0.4 would be the trigger that validates this downside risk.
Horizon
1-3 yr $435.53 (27-analyst consensus) — fundamentals + valuation re-rating. 5 yr $637.67 at ~12% CAGR — compounding case rests on the competitive position widening. 10 yr $945.93 if current growth sustains into durable earnings power.

ONC vs the Top Picks average

PillarONCBook avgDiff
Quality6083-23
Growth9589+6
Value5476-22

Average of today's Top 30 (mean score 82.6); size and sector limits also decide the book.

Trend
+15.9 over 82 daily scores
From 51.9 (Jun 22) → 67.8 (now)

One point per daily run; read From → To for the actual range.

ONC at a glance

THE BULL RANKINGS SCORECARD67.8/ 100 · BULL SCOREPEER MEDIANQUALITY60.4GROWTH95.0VALUE54.4Reverse-DCF · Price implies ~12% growth a year from here.
PRICE vs OUR DCF FAIR VALUE$301$597FAIR-VALUE RANGE$354PRICEOur DCF fair value ~$395 · price $354 is 10% below it.
WHERE THIS SCORE SITS0255075100ONC 67.8Top 13% of 1,709 companies on the quality-growth score.
PRICE IN ITS 52-WEEK RANGE$354LOW $254HIGH $385Trading at the 77th percentile of its 52-week range ($254–$385).

Same audited fundamentals as the score, unless a card says otherwise.

Analyst estimate revisions

30-day change-0.3%
90-day change+5.3%
Forward EPS estimate$10.25

Over the last 90 days, what analysts expect ONC to earn is materially higher (+5.3%). The estimate is derived from price and forward P/E captured at the same instant, so a moving share price does not move this number — only a changed forecast does.

Estimates move both ways and are not part of the Bull Rankings score. Biggest movers →

Shares to buy
5
Position size
$1,772
3.5% of portfolio
Stop price
$265.85
25% below $354.47
$ at risk if stopped
$443.09
budget $500.00 · 1% of portfolio

Math only: excludes commissions, slippage and gap risk. Inputs stay in your browser.

The Bull Rankings deep dive

Analysis as of · figures are as written that day and are not updated. Today's numbers are in the cards above.

Written by the Bull Rankings model from fundamentals as of , and checked against those figures. How we source & verify every figure →

The Bull Rankings scorecard — our quality-growth score is 69.9 / 100, built from three pillars scored 0–100: Quality 61, Growth 97, Value 58 (valuation is judged against sector peers). At today's price, our reverse-DCF read says the market is implicitly betting on free-cash-flow growth of about 9% a year next year, fading to 3% a year by year ten — a gauge of how much optimism is already in the stock.

THE BULL RANKINGS SCORECARD69.9/ 100 · BULL SCOREPEER MEDIANQUALITY60.9GROWTH96.8VALUE58.0Reverse-DCF · Price implies ~9% growth a year from here.

The thesis

QUALITY VS GROWTHweaker quality →strongerfasterslowergrowthONCVs Biotechnology — a compounder — strong and still growing.

The market just priced a 67x multiple on earnings for a company that grew revenue 34.3% in the year to the quarter ended 2026-06-30. That’s not a bargain, but it’s not a lottery ticket either. Our model gives BeOne Medicines AG a Quality-growth score of 69.9, with the strongest pillar being Growth at 97 and the weakest Value at 58. The growth engine is real: BRUKINSA, TEVIMBRA, and the rest of the oncology portfolio are pulling patients and payers into a widening franchise. The problem isn’t the top line; it’s the price tag. The model’s reverse DCF says today’s $375.80 implies roughly 9% annual free-cash-flow growth (in year one, slowing to 3% a year by year ten). That’s modest when the company’s revenue is still expanding at 34.3% and the PEG sits at 1.07. Either the Street is underestimating how long growth can stay this high, or it expects that growth to fade fast. The bull case leans on the 97 score for Growth; the bear case fixes on the 58 for Value and the diluting shareholders signal.

What the business actually is

REVENUE TO CASHRevenue$6.1b · 100%Net income$655.7m · 10.7%Free cash flow$1.3b · 21.7%Cash flow exceeds reported profit — high-quality earnings.

BeOne Medicines sells oncology drugs. BRUKINSA, a small-molecule BTK inhibitor, treats blood cancers. TEVIMBRA, an anti-PD-1 antibody, fights solid tumors and blood cancers. SYLVANT targets multicentric Castleman disease. BAITUOWEI is aimed at breast cancer in premenopausal and perimenopausal women. PARTRUVIX covers various solid tumors. The commercial stage products already generate cash, while the clinical pipeline keeps the growth runway in view. The revenue engine is built on repeat prescriptions for chronic therapies and expanding label expansions across geographies.

Why it can (or can't) keep compounding

The durability story starts with returns. ROE sits at 12.7% in the quarter ended 2026-06-30, decent for a biotech but not eye-popping. The profit margin is healthier at 10.7%, showing pricing power in a crowded field. The moat isn’t a fortress; it’s a head start in multiple tumor types and the clinical data that keeps regulators and payers approving new indications. Competitors can copy molecules, but duplicating a decade of real-world evidence and payer relationships takes years. Our model flags “diluting shareholders” as a caution, which means the company is likely tapping equity to fund the next wave of trials and launches. That dilution chips away at per-share gains even if the pie grows. Still, the growth pillar at 97 suggests the pipeline has so far outrun the dilution.

The valuation question

The market cap is $42.5 billion and the share price $375.80, a P/E of 67. The PEG of 1.07 says that multiple is roughly in line with expected earnings growth. Our model’s reverse DCF goes further: it says today’s price embeds roughly 9% annual free-cash-flow growth (in year one, slowing to 3% a year by year ten). That’s a bet on BRUKINSA’s next label expansion, TEVIMBRA’s penetration in China, and PARTRUVIX’s eventual approval. Revenue grew 34.3% in the year to the quarter ended 2026-06-30, but free cash flow of $1.3 billion is already a rounding error against the market cap. The 67 P/E only works if earnings keep compounding. Anything less—slower label uptake, payer pushback, or clinical setbacks—means the multiple has to compress. Optimism is priced into the P/E, if not into the cash-flow math.

The bear case

The weakest pillar is Value at 58, and the strongest skeptic’s argument is simple: at 67 times earnings, the stock already assumes a lot. The reverse DCF’s 9% implied free-cash-flow growth sits well below the 34.3% revenue growth, so the price assumes growth cools sharply. The model’s “diluting shareholders” signal confirms the suspicion that the company is funding growth with equity, turning future earnings into a smaller slice of a larger pie. If the clinical pipeline stalls or payer resistance stiffens, the multiple will reprice lower.

What would change our mind

BULL SCORE OVER TIME69.9Jun 22Aug 27Ranged 52–70 over 49 trading days · now 69.9 (up +18).

Three metrics would flip the thesis. First, if the PEG ratio drops below 0.9, the Value pillar would firm up and the discount to implied growth would shrink. Second, if the company stops diluting shareholders—evidenced by flat or falling share count over two consecutive quarters—the dilution risk would fade. Third, if profit margins cross 15%, the durability case would strengthen even if revenue growth cools. Until then, the Growth pillar carries the story, and the price is betting on 9% free-cash-flow growth next year, slowing to 3% a year by year ten.

BeOne Medicines AG (ONC): score, valuation & FAQ

BeOne Medicines AG (ONC) is a Biotechnology company that scores 67.8 out of 100 on the Bull Rankings quality-growth model — a solid, above-average reading. The score blends three pillars — quality (durable returns, healthy margins, low leverage), growth (revenue and earnings), and value (valuation versus sector peers) — into one number, refreshed daily; it is a screen, not a buy recommendation.

Its strongest graded signals are Rev (A) and PEG (A-). On valuation, ONC sits about 10% below our discounted-cash-flow fair value (a margin of safety) — the current price implies free cash flow growing about 12% next year, slowing to 4% a year by year ten.

Is ONC a good stock to buy?

Bull Rankings scores ONC 67.8 out of 100 on its quality-growth model, which is a solid, above-average reading. That is driven by Rev (A) and PEG (A-). A score is a quantitative screen of BeOne Medicines AG's fundamentals, not personalised financial advice — weigh it against your own time horizon and risk tolerance, and read the risk factors below before acting.

Why does ONC score 67.8 on Bull Rankings?

The score leans on growth at 95.0 out of 100, with value the weakest pillar at 54.4 — the three combine geometrically, so a weak one cannot be papered over by a strong one. ONC earns its highest marks on Rev (A) and PEG (A-). Each signal is graded against sector-aware thresholds rather than one absolute bar, so ONC is measured against Biotechnology peers, not against the market as a whole.

Is ONC overvalued or undervalued?

Based on $354.47, ONC sits about 10% below our discounted-cash-flow fair value (a margin of safety) — the current price implies free cash flow growing about 12% next year, slowing to 4% a year by year ten. It trades at a 63.4x P/E (graded C). Discounted-cash-flow estimates are sensitive to growth and discount-rate assumptions, so treat this as a cross-check, not a price target.

What are the main risks of investing in ONC?

The price already embeds a P/E of 65.1, far above sector averages, and the Bull Rankings model flags diluting shareholders, meaning any aggressive buy‑back or share‑issuance could erode per‑share earnings. If BRUKINSA’s next‑line trials stumble or reimbursement pressures tighten, the high multiple will compress sharply, confirming the bear case. A sustained rise in debt‑to‑equity beyond 0.4 would be the trigger that validates this downside risk.

New to these metrics? See the guides and the methodology.

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