Bull Rankings model

Sarepta Therapeutics, Inc. (SRPT) stock analysis

Biotechnology. Scored on the same transparent model behind the daily rankings.

Biotech & Gene Editing
★
SRPT
Sarepta Therapeutics, Inc. · Biotechnology
19.4Score
$17.85Oct 9 close$1.9B
1Y Target$21.64Analyst consensus · 22 analysts
5Y Target$37.84Compound horizon
10Y Target$67.63Long-dated conviction
FCF$82mTTM · 06/26
C-
FCF $82m — barely positive; fragile cash position · TTM from SEC filings (OCF − CapEx), four quarters to 06/26.
Rev-20.4%TTM YoY
F
Revenue -20.4% — severe decline · Latest four quarters of revenue vs the four before them, from SEC filings.
D/E0.70
C+
D/E 0.70 — above the Healthcare debt median (≈75th pctile)
P/S*1.0x
A-
P/S 1.0x — cheaper than most Healthcare peers (≈25th pctile)
PEG*—
—
PEG n/a — no positive earnings to base it on

* P/S replaces P/E — no positive earnings to divide by

* PEG n/a — no positive earnings to base it on

Targets: 1-year is analyst consensus where covered, 5- and 10-year are model estimates; the DCF is a cross-check, not a target. Methodology

Quality-growth score · 19.4
Quality22.2
Growth15.0
Value21.9
Why this score
  • Diluting shareholders
Entry · Margin of safety
52-week rangeNear 52-week low
28% off the 12-month high
vs DCF fair value91% aboveest. fair value ~$9
What the price assumes: free cash flow growing about 15% next year, slowing to 4% a year by year ten — vs a starting rate of ~-5% our model takes as the middle of three readings — analyst estimates, last year's revenue growth, and the company's own multi-year record.
Quality signals
Gross profitability61% · Agross profit ÷ total assets — not in the score
ROIC-7.4% · Freturn on invested capital — leads the quality score

Model-generatedWritten from the fundamentals then; figures in the text are as of that day, today's are above · Editorial standards

Why now
The bull case hinges on Sarepta’s expanding exon‑skipping franchise – EXONDYS 51, VYONDYS 53 and AMONDYS 45 – which together lock in a growing pool of Duchenne patients and generate $82 m of free cash flow at a market cap of $2.4 b. Even with a recent revenue decline of -36.2% YoY, the Bull Rankings model flags a Value pillar of 61, indicating the stock is priced for a ~20%/yr free‑cash‑flow growth assumption that far outpaces the actual revenue trend, leaving upside if the exon‑skipping pipeline ramps up. The thesis rests on the ability of these approved therapies to capture additional market share and drive cash conversion, delivering a compounding cash‑flow engine.
Moat
Sarepta’s moat derives from its proprietary RNA‑targeted and exon‑skipping technology, protected by extensive patents that prevent competitors from easily replicating the precise sequence designs needed for Duchenne treatments. Each approved product requires a confirmed mutation amenable to a specific exon skip, creating a high switching cost for patients and clinicians who are locked into Sarepta’s dosing regimens and safety data, cementing its position as the go‑to supplier for this ultra‑rare indication.
Risk
The bear case centers on the steep revenue contraction of -36.2% YoY and a negative profit margin of -9.8%, signaling that the current product mix is not yet profitable and that any delay in new exon‑skipping approvals could deepen losses. Coupled with a debt‑to‑equity of 0.7 and a weak Growth pillar (15) in our model, the stock is vulnerable to cash‑burn concerns; a sustained miss on upcoming regulatory milestones would confirm the dilution signal and push the price toward the 52‑week low of $14.68.
Horizon
1-3 yr $21.64 (22-analyst consensus) — catalyst-driven; binary events dominate. 5 yr $37.84 — requires the platform / technology to reach commercial scale. 10 yr $67.63 — return distribution heavily skewed.

SRPT vs the Top Picks average

PillarSRPTBook avgDiff
Quality2283-61
Growth1589-74
Value2276-54

Average of today's Top 30 (mean score 82.6); size and sector limits also decide the book.

Trend
-20.7 over 82 daily scores
From 40.1 (Jun 22) → 19.4 (now)

One point per daily run; read From → To for the actual range.

SRPT at a glance

THE BULL RANKINGS SCORECARD19.4/ 100 · BULL SCOREPEER MEDIANQUALITY22.2GROWTH15.0VALUE21.9Reverse-DCF · Price implies ~15% growth a year from here.
PRICE vs OUR DCF FAIR VALUE$8$10.5FAIR-VALUE RANGE$17.9PRICEOur DCF fair value ~$9.4 · price $17.9 is 91% above it.
WHERE THIS SCORE SITS0255075100SRPT 19.4Ranks above 8% of 1,709 companies on the quality-growth score.
ONE-YEAR MOVE VS ITS BETAFLATThis stock-18%Trailing one-year price change. Price history is not an inputto the Bull Rankings score.

Same audited fundamentals as the score, unless a card says otherwise.

Analyst estimate revisions

30-day change-6.2%
90-day change-10.0%
Forward EPS estimate$2.41

Over the last 90 days, what analysts expect SRPT to earn is materially lower (-10.0%). The estimate is derived from price and forward P/E captured at the same instant, so a moving share price does not move this number — only a changed forecast does.

Estimates move both ways and are not part of the Bull Rankings score. Biggest movers →

Shares to buy
112
Position size
$1,999
4.0% of portfolio
Stop price
$13.39
25% below $17.85
$ at risk if stopped
$499.80
budget $500.00 · 1% of portfolio

Math only: excludes commissions, slippage and gap risk. Inputs stay in your browser.

The Bull Rankings deep dive

Analysis as of · figures are as written that day and are not updated. Today's numbers are in the cards above.

Written by the Bull Rankings model from fundamentals as of , and checked against those figures. How we source & verify every figure →

The Bull Rankings scorecard — our quality-growth score is 27.9 / 100, built from three pillars scored 0–100: Quality 22, Growth 15, Value 65 (valuation is judged against sector peers). At today's price, our reverse-DCF read says the market is implicitly betting on free-cash-flow growth of about 16% a year next year, fading to 4% a year by year ten — a gauge of how much optimism is already in the stock.

THE BULL RANKINGS SCORECARD27.9/ 100 · BULL SCOREPEER MEDIANQUALITY22.2GROWTH15.0VALUE65.1Reverse-DCF · Price implies ~16% growth a year from here.

The thesis

Sarepta’s current price of $18.95 sits on the cheap side of the biotech peer set, reflected in a Value score of 65. That alone should make the stock attractive, but the real driver is the company’s Quality pillar at 22, which our model interprets as a solid, defensible platform. The Growth pillar lags at 15, a reminder that the upside is limited by the present revenue trajectory. In the quarter ended 2026‑06‑30, revenue fell -20.4% YoY, and the firm posted a -6.9% profit margin and -8.9% ROE. Yet the market is pricing in a free‑cash‑flow growth of about 16% in year 1, tapering to 4% by year 10. That implied growth far exceeds the negative revenue trend, meaning the price already assumes a turnaround. If that turnaround materializes, the upside is significant; if not, the stock is over‑valued.

What the business actually is

PROFITABILITY & RETURNSNET MARGIN-6.9%ROIC-7.4%ROE-8.9%GROSS PROFIT / ASSETS61.1%Not yet profitable on invested capital — a growth or turnaround bet.

Sarepta is a commercial‑stage biopharma that develops RNA‑targeted therapies for rare diseases. Its flagship products are exon‑skipping medicines for Duchenne muscular dystrophy: EXONDYS 51 (exon 51), VYONDYS 53 (exon 53), and AMONDYS 45 (exon 45). These drugs serve a niche patient population that requires a specific genetic mutation to be amenable to the therapy. The company also pursues a broader siRNA platform and gene‑therapy research, but the revenue engine today is dominated by the Duchenne line.

Why it can (or can't) keep compounding

The moat is the proprietary siRNA platform that enables precise exon skipping. Competitors would need to replicate the complex delivery system and secure the same mutation‑specific approvals, a process that can take a decade and billions of dollars. Sarepta’s free‑cash‑flow of $82 m in the trailing twelve months shows that the business is generating cash, albeit with a -6.9% margin that signals limited pricing power. The Debt‑to‑Equity of 0.7 indicates modest leverage, giving the company room to invest in R&D or acquisitions. The strongest model signal, Diluting shareholders, warns that the company may issue more shares to fund growth, which could erode per‑share value if the upside doesn’t materialize.

The valuation question

WHAT THE PRICE ASSUMES vs THE BUSINESS0%PRICE IMPLIES+16%REVENUE GROWTH-20%Price assumes growth accelerates beyond its recent pace.

Using the P/S ratio of 1 and a market cap of $2.0 b, the price implies a sales multiple that is lower than many biotech peers, reinforcing the Value score. The reverse‑DCF tells us the market expects 16% FCF growth in year 1, declining to 4% by year 10. Compared to the -20.4% revenue decline, the implied growth is aggressive. If the company can reverse its revenue slide and lift margins, the price would be justified. Conversely, if revenue continues to fall, the valuation is already too high. The analyst consensus of $21.86 a year from now, with a range of $5–$38, reflects this uncertainty.

The bear case

The most damning figure is the -20.4% revenue growth YoY. A negative top line in a specialty‑drug company that relies on a narrow patient cohort is a red flag. If the market continues to shrink, the company’s ability to generate cash will falter, and the Diluting shareholders signal could materialize, further compressing value. The current -6.9% profit margin and -8.9% ROE suggest the business is not yet profitable, and the price assumes a turnaround that may not occur.

What would change our mind

BULL SCORE OVER TIME27.9Jun 22Sep 23Ranged 28–43 over 69 trading days · now 27.9 (down -12.2).
  1. Revenue growth turning positive: If revenue growth turns positive, the implied growth would align more closely with the model’s 16% starting rate.
  2. Debt‑to‑Equity falling below 0.5: A stronger balance sheet would reduce dilution risk and improve the Quality pillar.

Sarepta Therapeutics, Inc. (SRPT): score, valuation & FAQ

Sarepta Therapeutics, Inc. (SRPT) is a Biotechnology company that scores 19.4 out of 100 on the Bull Rankings quality-growth model — a weak reading. The score blends three pillars — quality (durable returns, healthy margins, low leverage), growth (revenue and earnings), and value (valuation versus sector peers) — into one number, refreshed daily; it is a screen, not a buy recommendation.

Its strongest graded signals are P/S (A-), while FCF (C-) and Rev (F) rate weaker. On valuation, SRPT sits about 91% above our discounted-cash-flow fair value — the current price implies free cash flow growing about 15% next year, slowing to 4% a year by year ten.

Is SRPT a good stock to buy?

Bull Rankings scores SRPT 19.4 out of 100 on its quality-growth model, which is a weak reading. That is driven by P/S (A-). A score is a quantitative screen of Sarepta Therapeutics, Inc.'s fundamentals, not personalised financial advice — weigh it against your own time horizon and risk tolerance, and read the risk factors below before acting.

Why does SRPT score 19.4 on Bull Rankings?

It grades evenly across the three pillars — quality 22.2, growth 15.0, value 21.9 out of 100 — so no single pillar is carrying the score. SRPT earns its highest marks on P/S (A-), and is held back by FCF (C-) and Rev (F). Each signal is graded against sector-aware thresholds rather than one absolute bar, so SRPT is measured against Biotechnology peers, not against the market as a whole.

Is SRPT overvalued or undervalued?

Based on $17.85, SRPT sits about 91% above our discounted-cash-flow fair value — the current price implies free cash flow growing about 15% next year, slowing to 4% a year by year ten. Discounted-cash-flow estimates are sensitive to growth and discount-rate assumptions, so treat this as a cross-check, not a price target.

What are the main risks of investing in SRPT?

The bear case centers on the steep revenue contraction of -36.2% YoY and a negative profit margin of -9.8%, signaling that the current product mix is not yet profitable and that any delay in new exon‑skipping approvals could deepen losses. Coupled with a debt‑to‑equity of 0.7 and a weak Growth pillar (15) in our model, the stock is vulnerable to cash‑burn concerns; a sustained miss on upcoming regulatory milestones would confirm the dilution signal and push the price toward the 52‑week low of $14.68.

New to these metrics? See the guides and the methodology.

More Biotechnology stocks by score

All Healthcare rankings →

Analyze another ticker →