COMPARE · Data as of August 27, 2026
ALNY vs NKTR
Verdict: Side-by-side breakdown using the Bull Rankings model. ALNY scored 75.1, NKTR scored 25.8 — ALNY leads.
Compare another set
ALNY
Alnylam Pharmaceuticals, Inc.
75.1
$236.56 · $31.7B
fundamentals as of
Score gap
49.3
ALNY leads
NKTR
Nektar Therapeutics
25.8
$74.55 · $2.5B
fundamentals as of
At a glance · who leads each dimension, on the model's own rules
- Fastest growthALNY+65.2%
- Strongest balance sheetNKTR0.15
- Highest qualityALNY67 / 100
Side by side · every name on one set of axes
The model, pillar by pillar (0–100 each)
ALNY
stronger →← stronger
NKTR
67
Qualityreturns · margins · balance sheet
18
99
Growthrevenue & earnings expansion
14
64
Valuevaluation vs sector peers
69
ALNY is stronger on 2 of 3 pillars.
Fundamentals, head-to-head
ALNY
NKTR
$465mC
FCF
-$234mF
+65.2%A
Rev
-43.9%F
2.21D
D/E
0.15B+
41.2xC
P/E
—
0.45A
PEG
0.31A
—
P/S
46.6xD
Winner per row is the stronger grade; where grades tie, the better figure breaks it. A true tie or a missing value shows no highlight.
Valuation · DCF cross-check
ALNY
NKTR
190% above
Price vs fair valuelower is cheaper
—
~43%/yr
Growth the price implies10-yr FCF · lower = less priced in
—
-74%
1-yr DCF upside
—
-65%
5-yr DCF upside
—
-48%
10-yr DCF upside
—
The DCF is a cross-check on intrinsic value, separate from the quality-growth score above.
Model signals
ALNY
Why this score
- Diluting shareholders
NKTR
Why this score
- Diluting shareholders
The companies
ALNYAlnylam Pharmaceuticals, Inc.
Why now
Biotechnology · market cap $31.7b. Down 52% from 52-week high of $495.55 — deep drawdown territory. Revenue growing +65% — in hypergrowth territory. PEG 0.45 — paying under fair value for the growth rate. 26 sell-side analysts rate this a Buy with a mean 1-yr target of $370.20 (implying +56% upside).
Moat
Net margin 20% beats the market median by a meaningful margin — the company is keeping more of every revenue dollar than the average S&P constituent. ROE 54% — top-decile capital efficiency. Either pricing leverage, low capital intensity, or aggressive buybacks; the durability story depends on which. Pharma moat is patent runway + pipeline depth — a single approved molecule funds the next generation of bets. Late-stage trials carry binary readouts that swing valuation 30%+.
Risk
D/E 2.21 is elevated — limits strategic flexibility and raises refinancing exposure if rates stay higher for longer. Down 52% from the 52-week high — the market is pricing in something the screen can't see; verify the bear case before sizing up. Trailing P/E 41x sits well above the S&P median (~20x) — multiple compression is a real risk if revenue growth decelerates.
NKTRNektar Therapeutics
Why now
Biotechnology · market cap $2.5b. Down 32% from 52-week high of $109.00 — deep drawdown territory. Revenue -44% — in contraction; any catalyst that reverses this triggers re-rating. PEG 0.31 — paying under fair value for the growth rate. 10 sell-side analysts rate this a Strong Buy with a mean 1-yr target of $144.40 (implying +94% upside).
Moat
Pharma moat is patent runway + pipeline depth — a single approved molecule funds the next generation of bets. Late-stage trials carry binary readouts that swing valuation 30%+.
Risk
Free cash flow is negative (-$234m) — capital raises or debt issuance likely required; dilution / leverage risk. Revenue contracting -44% — the operational turn is not yet visible in the top line. Down 32% from the 52-week high — the market is pricing in something the screen can't see; verify the bear case before sizing up.
Verdict — model-derived comparison
Generating verdict… typically 5–10 seconds
Not investment advice. The Bull Rankings publishes a quantitative ranking model and accompanying analysis for general informational purposes only. Nothing on this page is a recommendation to buy, sell, or hold any security; nothing is personalized to your circumstances, risk tolerance, or tax situation. Investing carries the risk of loss — invest at your own risk and consider consulting a licensed financial professional before acting on anything you read here. See terms and methodology for full disclosures.
Where ALNY and NKTR diverge
On the headline score the gap is 49.3 points in favor of ALNY. They get there differently, though — each leads on a different pillar, so the better pick depends on which you weight.
- GrowthALNY 98.5 · NKTR 13.8ALNY +84.7
- QualityALNY 66.8 · NKTR 18.0ALNY +48.8
- ValueALNY 64.4 · NKTR 69.0NKTR +4.6
Pillars run 0–100 against sector peers, so a score is a statement about a company relative to its own industry rather than to the other name here. A wide Value gap usually means the market already prices the difference in quality or growth — which is the trade-off this comparison comes down to.